Allen from Shawnee on 1/4/2020 12:08:49 PM:
Having done the whole trail multiple times, this is how I would do it. I would park my car at the Amtrak station in Kirkwood MO., they allow this, just tell them, (be sure to book space for your bikes well in advance, they only have 4 per train). Then take the train to Sedalia and ride back to St Charles. Then get an Uber or some ride back to my car in Kirkwood, then come back to get the bikes in St. Charles. You can ride from St Charles to Kirkwood but you would need to be comfortable with riding city streets. There are routes available on this site to get there. I feel getting an Uber to haul 2 bikes and luggage might be difficult.
I know everyone feels differently about the parts of the trail they like. This is just my opinion based on ease and cost of transportation, plus experience of riding the trail.
Whatever you do have a good trip and be sure to stop and smell the roses.