Trek on 4/5/2010 2:57:20 PM:
Other than a couple of small sections, we've been on it all except Clinton to Sedalia and have found all routes taken to be a good time. Sedalia to Boonville as well as Hermann both directions for several miles seem to be peacefull and less crowded than the Rocheport area or the eastern end around Augusta to St. Charles.
On the other hand, if you're looking for some good places to stay and eat, try the Rocheport area.....bistro at the winery, Hotel Frederick in Boonville, Hermann area....Hermann Hill B&B/cottages, Stone Hill winery, etc.....the old main street in St. Charles is worth the trip too.
Go with your gut ideas....you probably know whether you like to visit wineries or stay in B&B's, etc. or if you'd more rather be away from civilization.