Darrell from Jefferson City, Mo. on 6/26/2011 7:57:29 AM:
The answer to your question is, no.
My question, what signage are you talking about?
Strictly speaking elevation, Boonville -to- Pilot Grove you are generally going up, but not from Pilot Grove to Boonville. Boonville to Pilot Grove seems more exhaustive than most parts, except Cliffton City to Sedalia, it is the toughest and most enjoyable to me.
You can click on Katy Trail Home, above, go to Latitude / Longitude and then click on a trail elevation chart. Not sure you can trust it though, I am convinced that between Boonville and Sedalia the trail go up, in both directions.