Chris J from Centralia, IL on 4/4/2013 5:22:23 PM:
I don’t know if you are looking for safe, scenic, or just traveling from Missouri-Southern Illinois-Kentucky, but you have several options: 1. Exit the Katy at Marthasville, cross the bridge at Washington and make your way southeast via some treacherous cycling roads to Chester to pick up the Trans Am route. 2. Make your way from St Charles to the Chain-of-Rocks cycling-only bridge across the Mississippi. Take one of the Madison County Bike trails and work east, then south on 2-lanes and county roads towards Murphysboro, IL. 3. Use GoogleMaps-Bike to chose your route then ask specific questions about a section of route on this site. I would choose option 2 and head east to Illinois Rt 4, then south. Good luck, there is no direct route, even be car.